NKH 477 hydrochloride ( Colforsin dapropate )

产品货号. M11605 CAS No. 138605-00-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

NKH 477 hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

NKH 477 hydrochloride (Colforsin dapropate) is a water-soluble analog of Forskolin and a potent activator of adenylyl cyclase.
产品描述

NKH 477 hydrochloride (Colforsin dapropate) is a water-soluble analog of Forskolin and a potent activator of adenylyl cyclase, shows some selectivity for cardiac (type V) adenylyl cyclase; increases cAMP accumulation in HEK293 cells stably overexpressing type V more than forskolin; A PKA activator.Heart Failure Approveed
同义词

Colforsin dapropate
通路

Metabolic Enzyme/Protease
靶点

Adenylate Cyclase
受体

Adenylate Cyclase
研究领域

——
适应症

——

CAS Number

138605-00-2
分子量

546.10
分子式

C27H43NO8.HCl
纯度

>98% (HPLC)
溶解度

——
SMILES

CC(C)CCC(O[C@@H]([C@@]1([H])C(C)(C)CC[C@H](O)[C@@]12C)[C@H](OC(C)=O)[C@]3(C)[C@]2(O)C(C[C@](C)(C=C)O3)=O)=O.[H]Cl
化学全称

(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-β-alanine, N,N-dimethyl-oxo-1H-naphtho[2,1-b]pyran-6-yl ester hydrochloride

1. Hosono M, et al. J Cardiovasc Pharmacol. 1992 Apr;19(4):625-34.
2. Toya Y, et al. J Mol Cell Cardiol. 1998 Jan;30(1):97-108.

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